COVID-19 Monoclonal Antibodies
For Prescribers

Overview

Monoclonal antibodies are a therapeutic agent under investigation for the treatment of COVID-19 and created by identifying pathogen-specific B cells of patients who have recently recovered from an infection or by utilizing mice genetically modified to have an immune system.

The genes of immune globulin heavy and light chains are recovered after the identified B cells then expressed to produce monoclonal antibodies.

FDA Authorization

The U.S. Food and Drug Administration has authorized three monoclonal antibody (mAb) treatments for emergency use: bamlanivimab (not available), the combination of etesevimab and bamlanivimab (not available), and the combination of casirivimab and imdevimab (currently available).

These treatments could help your immune system respond more effectively to the virus that causes COVID-19, reducing the chances that your symptoms will get worse. Your healthcare provider can help you decide if you’re eligible for mAb treatment.

Available mAb Therapies

bamlanivimab only

Bamlanivimab is an investigational medicine used to treat mild to moderate symptoms of COVID-19 in non-hospitalized adults and adolescents (12 years of age or older who weigh at least 88 pounds [40 kg]), and who are at high risk for developing severe COVID-19 symptoms or the need for hospitalization.

casirivimab and imdevimab

REGEN-COV (casirivimab with imdevimab to be administered together) is authorized for the treatment of mild to moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progressing to severe COVID-19 and/or hospitalization

bamlanivimab and etesevimab

Bamlanivimab and etesevimab are investigational medicines used together to treat mild to moderate symptoms of COVID-19 in adults and adolescents (12 years of age or older who weigh at least 88 pounds [40 kg]), and who are at high risk for developing severe COVID-19 symptoms or the need for hospitalization.

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